Laboratory of Applied
Microbial Ecology

Biomonitoring and Bioprospecting
Our research focuses on extremophilic bacteria, particularly psychrotolerants from Arctic and Antarctic regions, metallotolerants, and strains resistant to toxic compounds (including antibiotics). Using structural and functional genomics, we investigate their metabolic pathways and resistance mechanisms, with an emphasis on whole-genome sequencing and mobile genetic elements (MGEs). We apply advanced computational analyses to explore the ecological and evolutionary roles of MGEs and their biogeography.

We assess the taxonomic and functional diversity of microbial communities in pristine and anthropogenically-shaped environments, aiming to understand adaptation and seasonal microbiome dynamics. One of the key research areas is the ecological and molecular characterization of antibiotic resistance, supported by our custom-developed bioinformatic tools and curated databases.

We also conduct biomonitoring studies focused on the detection and analysis of pathogens, antibiotic resistance genes, and virulence factors across diverse environments. These efforts support applications in both human and veterinary medicine, enhancing our understanding of the environmental reservoirs and transmission routes of clinically relevant traits.

In parallel, we engage in bioprospecting of extreme environments for microbial strains, novel enzymes, and metabolites with high biotechnological potential, including their applications in regenerative agriculture and environmental biotechnologies.

Latest Papers

Prolonged disease remission of the chronic immunological skin disorder hidradenitis suppurativa with adjunctive bacteriophage therapy
Lene Bens, Tine Vanhoutvin, Sabrina Green, Sayali Gorivale, Madalena Almeida, Filip Romaniuk, Tom Hillary, Daan Jansen, Jelle Matthijnssens, Séverine Vermeire, João Sabino, Melissa Depypere, David Devolder, Isabel Spriet, Yves Debaveye, Paul De Munter, Jolien Onsea, Willem-Jan Metsemakers, Vera van Noort, Jean-Paul Pirnay, Maya Merabishvili, Jeroen Wagemans, Rob Lavigne, An Van Laethem
Nature Communications, 16, 11019 (2025)
Alpha-centractin is a novel substrate of SETD3 methyltransferase in vitro
Apolonia Witecka, Paulina Emmel, Klaudia Slusarczyk, Julia Z Kaminska, Michal Zarod, Takao Ishikawa, Jakub Drozak
PeerJ, 13, e20195 (2025)
Crystal structure, enzymatic and thermodynamic properties of the Thermus thermophilus phage Tt72 lytic endopeptidase with unique structural signatures of thermal adaptation
Sebastian Dorawa, Katarzyna Biniek-Antosiak, Magdalena Bejger, Anna-Karina Kaczorowska, Karol Ciuchcinski, Agnieszka Godlewska, Magdalena Plotka, Gudmundur O. Hreggvidsson, Lukasz Dziewit, Tadeusz Kaczorowski, Wojciech Rypniewski
Journal of Structural Biology, 217, 108230 (2025)

Latest News